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Target intelligence / Profile preview
Notch receptor 2 (NOTCH2)
- Target
- NOTCH2
- Molecular classification
- Receptor, Type I transmembrane protein
01
Overview
Notch receptor 2 (NOTCH2) is a type I transmembrane protein and a member of the Notch family of receptors. It plays a critical role in cell fate determination during embryonic development and adult tissue homeostasis by mediating intercellular signaling. Upon ligand binding, NOTCH2 undergoes proteolytic cleavages, releasing the NICD which regulates gene expression. Dysregulation is implicated in diseases like Alagille syndrome, Hajdu–Cheney syndrome, and various cancers.
- Other names
- Neurogenic locus notch homolog protein 2
02
Mechanism of action
Ligand binding induces proteolytic cleavage, releasing the NICD which translocates to the nucleus and activates target genes through interaction with CSL and Mastermind-like proteins.
03
Biological functions
Cell fate determinationEmbryonic developmentTissue homeostasisIntercellular signalingDifferentiationProliferationApoptosisImmune system functionTissue repairBone remodeling
04
Disease associations
Alagille syndromeHajdu–Cheney syndromeGastric cancerHematological malignanciesLung cancer
05
Safety considerations
Aberrant activation can promote oncogenesisDysregulation can disrupt normal tissue patterning
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