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Target intelligence / Profile preview
Neurogenic locus notch homolog protein 3 (NOTCH3)
- Target
- NOTCH3
- Molecular classification
- Receptor, Single-pass transmembrane receptor protein
01
Overview
NOTCH3 is a single-pass transmembrane receptor protein that plays a critical role in cell fate determination and tissue development. It mediates intercellular signaling and is particularly important for vascular smooth muscle cell function. Mutations in NOTCH3 are associated with CADASIL and other diseases, and it is being explored as a therapeutic target in cancer.
- Other names
- NOTC3_HUMANNotch homolog 3CADASIL gene
02
Mechanism of action
Inhibition of NOTCH3 signaling through antibody binding or other mechanisms.
03
Biological functions
Cell fate determinationIntercellular signalingVascular smooth muscle cell functionRegulation of gene transcription
04
Disease associations
CADASILLateral meningocele syndromeAlzheimer's diseaseCancer
05
Safety considerations
Potential for broad effects on Notch signaling pathways.Toxicity related to antibody-drug conjugates.
06
Interacting drugs
PF-06650808 (anti-NOTCH3 antibody-drug conjugate)
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