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Target intelligence / Profile preview
Neurogenin-2 (NEUROG2)
- Target
- NEUROG2
- Molecular classification
- Transcription factor, Basic helix-loop-helix (bHLH) protein
01
Overview
Neurogenin-2 (NEUROG2) is a neural-specific basic helix-loop-helix (bHLH) transcription factor that plays a crucial role in neurogenesis by specifying neuronal fate in ectodermal cells, promoting neuronal differentiation, and supporting the survival of midbrain dopaminergic neurons. It is expressed in neural progenitor cells of the developing central and peripheral nervous system. Mutations or dysregulation of NEUROG2 are associated with neurodevelopmental disorders but it is not currently considered a direct therapeutic target.
- Other names
- ATOH4BHLHA8NGN2NGN-2bHLHa8Atoh4Math4Angn-2neurogenin 2class A basic helix-loop-helix protein 8protein atonal homolog 4
02
Biological functions
Neuronal differentiationSpecification of neuronal fateRegulation of neural progenitor cell developmentSurvival of midbrain dopaminergic neurons
03
Disease associations
Neurodevelopmental disordersHereditary sensory and autonomic neuropathyPervasive developmental disorder
04
Safety considerations
Not established for therapeutic targeting; as a transcription factor, direct targeting presents challenges such as off-target effects and lack of druggability
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