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Neuroinflammation Pathway
- Molecular classification
- Biological pathway
01
Overview
The neuroinflammation pathway refers to the complex network of cellular and molecular events that mediate inflammatory responses within the central nervous system (CNS). This process is primarily orchestrated by CNS-resident immune cells, especially microglia, but also involves astrocytes, peripheral immune cell infiltration, and a variety of signaling molecules. Neuroinflammation is a key feature in many neurodegenerative diseases.
02
Mechanism of action
Targeting components within these pathways—such as inhibiting NF-kappa B signaling, modulating inflammasome activity, or controlling cytokine production
03
Biological functions
Immune responseSignal transductionCell signalingRegulation of gene expression
04
Disease associations
Neurodegenerative diseaseInflammationMultiple sclerosisAlzheimer's diseaseParkinson's diseaseAmyotrophic lateral sclerosis (ALS)
05
Safety considerations
Potential for immunosuppressionOff-target effects on other inflammatory pathwaysRisk of exacerbating infections
06
Biomarkers
IL-1βTNF-α
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