Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Neurokinin‑1 Receptor (NK‑1R)
- Target
- NK‑1R
- Molecular classification
- G protein-coupled receptor
01
Overview
The Neurokinin-1 Receptor (NK-1R), also known as Tachykinin receptor 1 (TACR1) or Substance P receptor (SPR), is a Class A G protein-coupled receptor (GPCR) that binds to members of the tachykinin family, primarily Substance P. Activation of NK1R mediates diverse physiological processes including pain transmission, inflammation, vasodilation, and emesis. NK1R is coupled to Gq/11 proteins, leading to activation of phospholipase Cβ (PLCB) and increased intracellular calcium levels. Antagonists targeting NK1 receptors, such as aprepitant, are clinically used to treat chemotherapy-induced nausea/vomiting.
- Other names
- Tachykinin receptor 1TACR1Substance P receptorSPR
02
Mechanism of action
Antagonism of substance P binding; inhibition of PLCβ/IP₃/Ca²⁺ signaling pathway
03
Biological functions
Pain transmission (nociception)Inflammation modulationVasodilationEndocrine and paracrine secretionModulation of cell proliferation and survivalHematopoiesisWound healingMicrovasculature permeabilityLeukocyte traffickingNeuromodulation
04
Disease associations
PainInflammationDepressionStressAnxietyEmesis (vomiting)Neurogenic inflammationPsychiatric disorders
05
Interacting drugs
Substance P
3 more in the full profile.
Beyond the preview
Go deeper on Neurokinin‑1 Receptor (NK‑1R).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Neurokinin‑1 Receptor (NK‑1R).