Neuroligin-1 (NLGN1)

Neuroligin-1 (NLGN1) is a postsynaptic cell adhesion protein encoded by the NLGN1 gene, belonging to the neuroligin family. It predominantly localizes to the postsynaptic membranes of excitatory (glutamatergic) synapses, where it acts as a ligand for presynaptic β-neurexins. Through trans-synaptic interactions, NLGN1 plays a crucial role in the formation, differentiation, and modulation of synapses in the central nervous system. Regulation of NLGN1, including its cleavage and phosphorylation by receptor tyrosine kinases such as TrkB, affects synaptic structure and functional plasticity. Aberrations in NLGN1 levels or sequence are linked to multiple neurodevelopmental, neuropsychiatric, and neurodegenerative conditions, making it a significant molecule in the study of brain disorders and synaptic biology[1][2][3][4].

Other names

NLGN1KIAA1070NLG1NL1neuroligin-1Neuroligin-1

Experimental mechanisms: Modulation of synapse formation and maintenance via interference with neurexin–neuroligin binding or NLGN1 phosphorylation. Compounds or strategies designed to modify NLGN1-dependent signaling may influence glutamatergic synaptic function[2][3].