Neuromedin B (NMB)

Neuromedin B is a bombesin-like peptide neuropeptide widely expressed in the mammalian central nervous system and gastrointestinal tract[1][4]. The human peptide consists of 32 amino acids, with a highly conserved C-terminal decapeptide crucial for receptor binding[1][2]. Neuromedin B exerts biological effects primarily through the neuromedin B receptor (NMBR), a G protein-coupled receptor (GPCR) broadly expressed in the brain and peripheral tissues[3][4]. Its functions include the regulation of body temperature, cell proliferation, blood glucose, blood pressure, and secretory processes. NMB and its receptor are research targets in oncology and metabolic diseases because of their roles in tumor growth, metabolism, and possibly feeding behavior. While not directly drugged in clinical practice, they remain accessible targets for preclinical small-molecule and peptide-based ligand development[1][3][4].

Other names

Neuromedin-BNeuromedin-B-32neuromedin-Bneuromedin-betaMGC2277MGC3936MGC17211

NMB binds and activates the neuromedin B receptor (NMBR), a G protein-coupled receptor, triggering intracellular signaling via G-proteins, including inhibition of adenylate cyclase, decrease in cAMP, and activation of protein kinase A and associated transcription factors, driving cell growth and anti-apoptotic responses[1][3].