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Target intelligence / Profile preview
Neuromedin B Receptor (NMBR)
- Target
- NMBR
- Molecular classification
- G protein-coupled receptor, 7-transmembrane receptor
01
Overview
The neuromedin B receptor (NMBR), also known as BB1, is a G protein-coupled receptor (GPCR) with seven transmembrane domains. Its endogenous ligand is neuromedin B. NMBR mediates various physiological functions by binding neuromedin B, which acts as a potent mitogen and growth factor for normal and neoplastic lung tissue and gastrointestinal epithelial cells. Antagonists targeting NMBR may have therapeutic potential for inhibiting tumor cell growth. Polymorphisms in the NMBR gene have been associated with susceptibility to schizophrenia.
- Other names
- BB1BB1RNMB-RBombesin Receptor 1Neuromedin-B-preferring bombesin receptor
02
Mechanism of action
Antagonists targeting NMBR may inhibit tumor cell growth.
03
Biological functions
Exocrine and endocrine secretions regulationSmooth muscle contraction modulationFeeding behavior influenceBlood pressure regulationBlood glucose levels modulationBody temperature modulationCell growth/proliferationSignal transduction
04
Disease associations
CancerSchizophrenia
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