Neuromedin U receptor 1 (NMUR1)

Neuromedin U receptor 1 (NMUR1) is a G protein-coupled receptor that binds the neuropeptides neuromedin U (NMU) and neuromedin S (NMS)[3][7][10]. It is predominantly expressed in peripheral tissues, notably the gastrointestinal tract, adipose tissue, pancreas, immune cells, heart, and vascular tissue, where it regulates a broad spectrum of physiological processes, including smooth muscle contraction, energy homeostasis, vasoconstriction, stress response, and immune modulation[2][10]. NMUR1 is implicated as a therapeutic target for metabolic disorders such as obesity, as well as for certain cancers and cardiovascular diseases[3][7][9]. Selective NMUR1 agonists and antagonists are studied for their potential to modulate these processes and as tools to elucidate NMUR1 function. Importantly, the receptor’s widespread distribution necessitates caution in drug development due to possible off-target or systemic effects[6][7].

Other names

NMU1 receptorGPR66FM-3SNORF62

Receptor agonists/antagonists modulate signal transduction via Gq/11 protein coupling, affecting calcium signaling, smooth muscle activity, and metabolic regulation[3][6].