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Neuromuscular junction synaptic transmission via SNAP25 cleavage by botulinum neurotoxin type A light chain protease activity leading to inhibition of acetylcholine release at motor nerve terminals
- Molecular classification
- Enzyme, Protease, SNARE protein substrate
01
Overview
Botulinum neurotoxin type A light chain proteolytically cleaves SNAP25 at the neuromuscular junction, preventing SNARE complex formation and subsequent acetylcholine release, leading to muscle relaxation or paralysis.
- Other names
- SNAP25 cleavage by BoNT/A at NMJBotulinum neurotoxin A light chain target at neuromuscular junctionBoNT/A inhibition of acetylcholine release
02
Mechanism of action
Zinc-dependent endopeptidase activity cleaving SNAP25, inhibiting SNARE complex formation and acetylcholine release at the neuromuscular junction.
03
Biological functions
NeurotransmissionSynaptic vesicle fusionAcetylcholine releaseMuscle contraction
04
Disease associations
BotulismMuscle spasticityDystoniaStrabismus
05
Safety considerations
Spread of toxin beyond injection siteAntibody formationDysphagiaMuscle weakness
06
Interacting drugs
Botulinum toxin type A
4 more in the full profile.
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