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Target intelligence / Profile preview
Neuronal Acetylcholine Receptor (nAChR)
- Target
- nAChR
- Molecular classification
- Ligand-gated ion channel, Receptor
01
Overview
Neuronal acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate fast synaptic transmission in the central and peripheral nervous systems. They are activated by the neurotransmitter acetylcholine and also respond to nicotine. nAChRs are pentameric proteins consisting of various combinations of α and β subunits, forming diverse subtypes with distinct pharmacological properties. They play key roles in synaptic plasticity, neurotransmitter release, cognitive functions, and are implicated in various neurological diseases, including Alzheimer's, schizophrenia, and addiction.
- Other names
- Nicotinic Acetylcholine Receptor (Neuronal)Neuronal Nicotinic Receptor
02
Mechanism of action
Agonist or antagonist binding to the receptor, causing a conformational change that opens or closes the ion channel.
03
Biological functions
Fast synaptic transmissionModulation of neurotransmitter releaseSynaptic plasticitySignal transduction
04
Disease associations
Alzheimer's diseaseSchizophreniaParkinson's diseaseEpilepsyDepressionAddiction
05
Safety considerations
Potential for addiction (nicotine)Side effects related to altered neuronal excitability
06
Interacting drugs
Acetylcholine
4 more in the full profile.
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