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Neuronal acetylcholine receptor subunit alpha-10 (nAChRα10)
- Target
- nAChRα10
- Molecular classification
- Ligand-gated ion channel, Ion channel, Nicotinic acetylcholine receptor subunit
01
Overview
The neuronal acetylcholine receptor subunit alpha-10 (nAChRα10) is a component of certain nicotinic acetylcholine receptors (nAChRs), ligand-gated ion channels. It forms heterooligomeric pentameric channels with the α9 subunit, creating functional α9α10 nAChRs. It is highly expressed in inner ear hair cells and involved in auditory processing. Mutations are linked to autosomal recessive deafness. Blockade or modulation may have implications for neuropathic pain management.
- Other names
- Cholinergic receptor nicotinic alpha 10CHRNA10
02
Mechanism of action
Nicotine blocks α9α10-containing nAChRs; Conotoxin RgIA is a selective antagonist of α9α10-containing nAChRs.
03
Biological functions
Ionotropic receptor activityModulation of auditory stimuliCation influxActivation of potassium currentsHyperpolarization of cell membranesPositive regulation of cytosolic calcium ion concentration
04
Disease associations
Autosomal recessive deafness type 25 (DFNB25)Neuropathic pain
05
Interacting drugs
Nicotine
1 more in the full profile.
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