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Target intelligence / Profile preview
Neuronal acetylcholine receptor subunit alpha-2 (nAChRα2)
- Target
- nAChRα2
- Molecular classification
- Ligand-gated ion channel, Receptor, Neuronal nicotinic acetylcholine receptor subunit
01
Overview
The neuronal acetylcholine receptor subunit alpha-2 (nAChRα2) is a protein encoded by the CHRNA2 gene. It is a subunit of nicotinic acetylcholine receptors (nAChRs), which are ligand-gated ion channels involved in synaptic transmission and various neurological processes, including learning, memory, and addiction. The α2 subunit typically combines with β subunits to form functional heteropentamers, such as α2β4 or α2β2. Drugs targeting these channels are being investigated for several diseases.
- Other names
- CHRNA2Acra2Cholinergic receptor, nicotinic alpha 2 (neuronal)
02
Mechanism of action
Agonist-induced opening of cation channel permeable to Na+, K+, and Ca2+
03
Biological functions
NeurotransmissionSynaptic transmissionModulation of neurotransmitter releaseRegulation of sleep/arousal cyclesLearning and memorySynaptic plasticityIon channel activity
04
Disease associations
SchizophreniaAlzheimer's diseasePainAnxietyNicotine addictionCognitive impairment
05
Safety considerations
Potential for addictionSide effects associated with cholinergic modulation
06
Interacting drugs
Acetylcholine
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