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Target intelligence / Profile preview
Nicotinic Acetylcholine Receptor Subunit Alpha-3 (nAChRα3)
- Target
- nAChRα3
- Molecular classification
- Ligand-gated ion channel, Cys-loop receptor superfamily, Nicotinic acetylcholine receptor (nAChR) subfamily
01
Overview
The Nicotinic Acetylcholine Receptor Subunit Alpha-3 (nAChRα3) is a subunit of a pentameric ligand-gated ion channel that mediates fast synaptic transmission. Upon binding of acetylcholine or other agonists, the channel opens, allowing influx of cations such as Na⁺, K⁺, and Ca²⁺, leading to neuronal depolarization and excitation. nAChRα3 is predominantly found in autonomic ganglia and adrenal medulla, and also in certain regions of the CNS. It plays a role in signal transmission from preganglionic to postganglionic neurons and is implicated in addiction mechanisms, particularly regarding ethanol. Specific subtypes of nAChRs exhibit distinct pharmacological properties.
- Other names
- CHRNA3Neuronal acetylcholine receptor subunit alpha-3
02
Mechanism of action
Agonist or antagonist binding to the nAChRα3 subunit, leading to conformational change and ion channel opening or blocking.
03
Biological functions
Fast synaptic transmissionIon transportNeuronal excitationModulation of synaptic strength/integration
04
Disease associations
AddictionEthanol dependence
05
Interacting drugs
Acetylcholine
8 more in the full profile.
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