Neuronal Acetylcholine Receptor Subunit Alpha-6 (nAChRα6)

The neuronal acetylcholine receptor subunit alpha-6 (nAChRα6 or CHRNA6) is a subunit of nicotinic acetylcholine receptors (nAChRs), which are ligand-gated ion channels primarily found in the nervous system. It is expressed in dopamine-releasing neurons in midbrain regions and plays critical roles in modulating dopamine release, reward-related behaviors, motor function, and addiction. Variants and altered function of CHRNA6 have been associated with nicotine dependence, alcohol dependence, cocaine dependence, bipolar disorder, dystonia, and Parkinson’s disease. Drugs targeting α6-containing nAChRs are being explored for treating addiction disorders and neurodegenerative diseases.

Other names

CHRNA6

Agonist binding to the receptor leading to conformational change and opening of the ion channel; Antagonist binding blocking the receptor and preventing activation.