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Neuronal acetylcholine receptor subunit beta-4
- Molecular classification
- Ligand-gated ion channel, Receptor, Nicotinic acetylcholine receptor subunit
01
Overview
Neuronal acetylcholine receptor subunit beta-4 is a subunit of the nicotinic acetylcholine receptor (nAChR), a ligand-gated ion channel that mediates fast synaptic transmission. It combines with alpha subunits to form functional heteromeric receptors. CHRNB4 is implicated in nicotine dependence, lung cancer, and frontotemporal dementia.
- Other names
- CHRNB4nAChR beta4 subunit
02
Mechanism of action
Agonist-induced cation channel opening
03
Biological functions
Neurotransmitter receptor activityIon channel activitySynaptic transmissionModulation of neurotransmitter releaseCholinergic neurotransmission
04
Disease associations
Tobacco addiction/nicotine dependenceFrontotemporal dementiaLung cancer
05
Safety considerations
Potential for off-target effects due to receptor subunit combinationsDrug-drug interactions affecting cholinergic signalingDevelopment of tolerance or dependence
06
Interacting drugs
Acetylcholine
1 more in the full profile.
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