Neuronal apoptosis

Neuronal apoptosis is the tightly regulated process of programmed cell death in neurons; it involves the activation of molecular pathways (e.g., caspases) that dismantle cellular components in an orderly manner and is crucial for removing surplus or damaged neurons during development and throughout life[1][2]. Dysregulation of neuronal apoptosis can contribute to neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases, as well as to developmental disorders and injuries[1][2][3]. Molecular triggers include internal signals (DNA damage, loss of survival factors) and external signals (activation of death receptors such as Fas or TNF receptor)[5]. Detectable by biomarkers such as caspase activation and DNA fragmentation, neuronal apoptosis is essential for brain health but is not a therapeutic target itself; rather, its molecular mediators (e.g., caspases, apoptosis-inducing factor) may serve as drug targets[2][5][4].

Other names

Programmed neuronal cell deathApoptosis in neuronsNeuronal programmed cell death