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Neuronal Calcium Channels (VGCCs)
- Target
- VGCCs
- Molecular classification
- Ion Channel, Voltage-Gated Ion Channel
01
Overview
Neuronal calcium channels are diverse voltage-gated ion channels essential for brain function through their roles in electrical signaling and neurotransmission. Their structure includes a central α₁ subunit with multiple auxiliary partners; they are tightly regulated both genetically and post-translationally. Dysfunction causes significant neurological disease burden.
- Other names
- Voltage-Gated Calcium ChannelsCaV ChannelsCalcium Channels
02
Mechanism of action
Inhibition of calcium channel activity.
03
Biological functions
Neurotransmitter releaseSynaptic plasticityGene expressionNeuronal excitabilitySignal transductionRhythmic firingPacemaker activity
04
Disease associations
EpilepsyMigraineAtaxiaTimothy SyndromeBrugada SyndromeLambert-Eaton Myasthenic SyndromeBipolar Disorder
05
Safety considerations
Neurological side effectsCardiac side effects (depending on subtype selectivity)
06
Interacting drugs
Gabapentinoids
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