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"Neuronal cell surface receptors" is a collective designation for the various classes of transmembrane proteins (such as G protein–coupled receptors, ionotropic receptors, enzyme-linked receptors, and adhesion molecules) expressed at the surface of neurons. These molecules are essential for neuronal communication, synaptic connectivity, and the specification of neural circuits. Their diversity supports precise wiring, neurotransmission, and plasticity in the nervous system. Major superfamilies include cadherins, neurexins, immunoglobulin superfamily proteins, leucine-rich repeat proteins, and various synaptic adhesion molecules[2][4][7]. As a group, they mediate diverse responses to neurotransmitters, neuropeptides, trophic factors, and extracellular matrix components, but as a term, it is not suitable for annotation as a therapeutic target without further specification. In summary, "Neuronal cell surface receptors" is an umbrella term and does not map to a single target entity appropriate for structured drug target annotation. For precise information, a specific receptor name (e.g., "N-methyl-D-aspartate receptor") is required.
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