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Neuronal guanine nucleotide exchange factor (NGEF)
- Target
- NGEF
- Molecular classification
- Guanine nucleotide exchange factor (GEF), Enzyme, Dbl family protein, Rho GTPase activator
01
Overview
Neuronal guanine nucleotide exchange factor (NGEF), also known as Ephexin-1 or ARHGEF27, is a Dbl family guanine nucleotide exchange factor predominantly expressed in the central nervous system. It acts downstream of Eph tyrosine kinase receptors, linking Eph/ephrin signals to RhoA, Rac, and Cdc42 GTPases, and is crucial for axon guidance, synaptic homeostasis, and cytoskeletal remodeling. NGEF is an enzymatic signaling hub, modulating actin dynamics in response to neuronal and developmental cues. Dysregulation of NGEF/Ephexin-1 function is implicated in various cancer types and neurological disorders, making it a relevant target for research into neurodevelopmental diseases and cancer therapies
- Other names
- Ephexin-1Ephexin1ARHGEF27Eph-interacting exchange proteinEphexinEPHEXINeph-interacting exchange protein
02
Mechanism of action
Drugs targeting NGEF would modulate Rho GTPase signaling by altering its exchange factor activity, thereby influencing cytoskeletal dynamics, axon guidance, and potentially cell proliferation and migration
03
Biological functions
Signal transductionCytoskeletal regulationNeuronal development (axon guidance, growth cone dynamics)Synaptic homeostasis and maturationMyelinationCell migration and proliferation
04
Disease associations
CancerNeurodevelopmental and brain disorders
05
Safety considerations
Modulating NGEF/Rho GTPase pathways can impact neuronal development, synaptic function, and cell migration, potentially leading to neurodevelopmental side effects or unwanted impacts on cancer progression if dysregulated
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