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Target intelligence / Profile preview
Neuronal hypoxia inducible, placenta associated (NHIP)
- Target
- NHIP
- Molecular classification
- Other (developmentally regulated gene), transcriptional regulator
01
Overview
NHIP (neuronal hypoxia inducible, placenta associated) is a primate-specific gene originally identified as LOC105373085 at chromosomal region 22q13.33. NHIP expression is induced by hypoxia and oxidative stress specifically in differentiated neurons and placental tissue. It regulates other genes involved in neuronal development, cell proliferation, and response to cellular stress. NHIP appears to play a protective role; reduced NHIP expression or activity in placenta and developing brain tissue is associated with increased risk for autism spectrum disorder (ASD), presumably due to decreased buffering of oxidative stress during development. It is currently under study as a potential biomarker for neurodevelopmental risk, but it is not considered a classic drug target type (such as a receptor or enzyme).
- Other names
- LOC105373085
02
Biological functions
Response to hypoxiaRegulation of neuronal developmentRegulation of cell proliferationResponse to oxidative stress
03
Disease associations
Neurodevelopmental disease (autism spectrum disorder—ASD)Potential biomarker for placental/neurodevelopmental stress response
04
Biomarkers
NHIP methylation and expression levels (potential biomarkers for ASD risk and for monitoring oxidative stress in placenta/brain)
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