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Target intelligence / Profile preview
Neuronal Ketone Body Utilization (NKBU)
- Target
- NKBU
- Molecular classification
- Metabolic process
01
Overview
Neuronal ketone body utilization refers to the process by which neurons in the brain take up and metabolize ketone bodies—primarily beta-hydroxybutyrate (BHB) and acetoacetate (AcAc)—as alternative energy substrates, especially during periods of low glucose availability. This metabolic adaptation is crucial for maintaining brain function and may offer neuroprotective effects.
- Other names
- Neuronal ketone metabolismKetone body uptake by neuronsBrain ketone metabolism
02
Mechanism of action
Not applicable; this is a physiological process, not a drug target.
03
Biological functions
Energy metabolismNeuroprotectionModulation of neuronal excitabilityGABA synthesisGlutamatergic transmission modulation
04
Disease associations
EpilepsyNeurodegenerative diseases (e.g., Alzheimer's disease)Metabolic stress
05
Safety considerations
Ketoacidosis (potential risk with uncontrolled ketogenesis)Electrolyte imbalances (during ketogenic diet)Gastrointestinal distress (during ketogenic diet initiation)
06
Interacting drugs
Ketogenic diet (indirectly influences)
1 more in the full profile.
07
Biomarkers
Blood ketone levels (BHB, AcAc)Expression levels of MCT1, MCT2, MCT4 in brain tissueActivity levels of BDH, SCOT/OXCT1, thiolase
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