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Target intelligence / Profile preview
Neuronal Nicotinic Acetylcholine Receptor α4β2 Subtype (nAChR α4β2)
- Target
- nAChR α4β2
- Molecular classification
- Ligand-gated ion channel, Receptor, Nicotinic acetylcholine receptor
01
Overview
The neuronal nicotinic acetylcholine receptor α4β2 subtype is a highly prevalent heteromeric ionotropic receptor critical for fast synaptic transmission in the CNS. Its unique structural features allow for diverse functional roles across multiple neural circuits. It serves as an important pharmacological target for neuropsychiatric conditions due to its involvement in cognition, addiction biology, mood regulation, pain processing—and its plasticity under chronic exposure conditions such as tobacco use makes it central to understanding substance dependence mechanisms.
- Other names
- alpha4 beta2 nAChRα4β2 nAChRNeuronal alpha4beta2 Nicotinic Receptor
02
Mechanism of action
Agonist-induced cation channel opening, leading to neuronal depolarization
03
Biological functions
Ion transportSynaptic transmissionNeuromodulationSignal transduction
04
Disease associations
AddictionEpilepsyCognitive dysfunctionMood disordersAutosomal dominant nocturnal frontal lobe epilepsyPain
05
Safety considerations
Potential for addiction (nicotine)Side effects related to cholinergic stimulationDesensitization and tolerance
06
Interacting drugs
Acetylcholine
1 more in the full profile.
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