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Target intelligence / Profile preview
Neuronal Nicotinic Acetylcholine Receptor α7 Subtype (α7 nAChR)
- Target
- α7 nAChR
- Molecular classification
- Ligand-gated ion channel, Cys-loop receptor, Nicotinic acetylcholine receptor, Receptor
01
Overview
The neuronal α7 nicotinic acetylcholine receptor (α7 nAChR) is a ligand-gated ion channel composed of five α7 subunits. It is highly permeable to calcium ions and exhibits rapid desensitization. Expressed throughout the CNS and PNS, it modulates synaptic activity, cognitive processes, and inflammation. It is implicated in diseases like schizophrenia, Alzheimer's, and cancer, and is a target for therapeutic interventions.
- Other names
- alpha-7 nicotinic receptorα7 nicotinic acetylcholine receptor
02
Mechanism of action
Agonist or antagonist binding to the receptor, modulating ion channel opening and calcium influx.
03
Biological functions
Modulation of synaptic activityRegulation of neurotransmitter releaseSynaptic plasticityCognitive processes (learning, memory, attention)NeurogenesisRegulation of calcium ion influxCholinergic anti-inflammatory pathway
04
Disease associations
SchizophreniaAlzheimer’s DiseaseInflammationStrokeMyocardial InfarctionSepsisCancerAtherosclerosis
05
Safety considerations
Rapid desensitizationPotential for off-target effects due to widespread distribution
06
Interacting drugs
Acetylcholine
3 more in the full profile.
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