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Neuronal Nicotinic Acetylcholine Receptor Alpha3Beta4 Subtype (α3β4 nAChR)
- Target
- α3β4 nAChR
- Molecular classification
- Cys-loop ligand-gated ion channel, Receptor, Ion channel
01
Overview
The neuronal nicotinic acetylcholine receptor (nAChR) alpha3beta4 subtype is a pentameric ligand-gated ion channel composed of α3 and β4 subunits. It is predominantly expressed in autonomic ganglia and certain brain regions, mediating fast synaptic transmission and modulating reward pathways. Activation of α3β4 nAChR leads to increased permeability for Na^+ and K^+ ions, resulting in rapid depolarization of postsynaptic membranes. It is implicated in nicotine dependence/addiction, representing a potential therapeutic target.
02
Mechanism of action
Ligand-gated ion channel activation/inhibition
03
Biological functions
Fast excitatory neurotransmissionModulation of reward pathwaysSynaptic transmissionIon transportSignal transduction
04
Disease associations
Nicotine dependenceAddictionCardiovascular regulation
05
Safety considerations
Potential for off-target effects due to structural similarity with other nAChR subtypesCardiovascular effects
06
Interacting drugs
Acetylcholine
9 more in the full profile.
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