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Target intelligence / Profile preview
Neuronal Nicotinic Receptor Alpha-7 Subtype (α7 nAChR)
- Target
- α7 nAChR
- Molecular classification
- Receptor, Ion channel, Ligand-gated ion channel
01
Overview
The neuronal nicotinic receptor alpha-7 subtype (α7 nAChR) is a homopentameric ligand-gated ion channel highly permeable to calcium ions (Ca²⁺), in addition to sodium (Na⁺) and potassium (K⁺). It is widely expressed in the central nervous system and peripheral tissues. It mediates fast synaptic transmission, modulates neurotransmitter release, and is involved in cognitive processes, neurogenesis and inflammation regulation. It has been implicated in neuroprotection, cognitive disorders like schizophrenia and Alzheimer's disease, and cancer progression.
- Other names
- Alpha 7 nicotinic acetylcholine receptorCHRNA7
02
Mechanism of action
Activation leads to rapid desensitization but also supports neuronal survival after excitotoxic stimuli via Ca²⁺ dependent mechanisms; inhibits pro-inflammatory cytokine release from immune cells.
03
Biological functions
Fast synaptic transmissionNeurotransmitter modulationCognitive processingImmune regulationAngiogenesisApoptosisCell migrationCell proliferationNeurogenesis
04
Disease associations
Neurodegenerative diseaseSchizophreniaAlzheimer's diseaseInflammationCancerSepsisStroke
05
Safety considerations
Activation leads to rapid desensitizationInvolved in cancer cell proliferation/metastasis
06
Interacting drugs
Acetylcholine
5 more in the full profile.
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