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Neuronal norepinephrine transporter (NET)
- Target
- NET
- Molecular classification
- Transporter, Solute Carrier Family 6
01
Overview
The neuronal norepinephrine transporter (NET), encoded by the SLC6A2 gene, is a transmembrane protein responsible for the reuptake of norepinephrine from the synaptic cleft back into presynaptic neurons. This process terminates noradrenergic signaling and plays a critical role in regulating mood, arousal, cognition, and autonomic function. NET is a therapeutic target for several classes of drugs, including antidepressants and psychostimulants, and dysregulation of NET has been implicated in various neuropsychiatric and cardiovascular disorders.
- Other names
- Norepinephrine transporterNoradrenaline transporterSLC6A2
02
Mechanism of action
Inhibition of norepinephrine reuptake
03
Biological functions
Neurotransmitter reuptakeTermination of noradrenergic signalingRegulation of synaptic norepinephrine levels
04
Disease associations
DepressionAnxiety disordersADHDPostural orthostatic tachycardia syndrome (POTS)Cardiovascular diseases
05
Safety considerations
Cardiovascular side effectsDrug interactionsPotential for abuse (with psychostimulants)
06
Interacting drugs
Tricyclic antidepressants
2 more in the full profile.
07
Biomarkers
rs5569 (genetic variant in SLC6A2)Promoter hypermethylation of SLC6A2
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