Neuronal PAS domain-containing protein 3 (NPAS3)

Neuronal PAS domain-containing protein 3 (NPAS3) is a member of the basic helix-loop-helix-PAS (bHLH-PAS) family of transcription factors, primarily expressed in the nervous system[1][2][3]. NPAS3 forms obligate heterodimers with the aryl hydrocarbon receptor nuclear translocator (ARNT), and together these complexes regulate transcription of specific target genes through direct DNA binding[1][3]. NPAS3 plays an important role in neurodevelopment, adult neurogenesis, and regulation of neural cell proliferation and apoptosis[1][2]. Genetic studies link NPAS3 mutations or altered function to neuropsychiatric conditions such as schizophrenia, autism spectrum disorder, and bipolar disorder[3]. Although its druggability potential is highlighted by the multi-ligand-binding architecture of the bHLH-PAS family, there are currently no known drugs directly targeting NPAS3[3].

Other names

Neuronal PAS domain protein 3BHLHE12MOP6PASD6Neuronal PAS3bHLHe12Basic-helix-loop-helix-PAS protein MOP6Class E basic helix-loop-helix protein 12Member of PAS protein 6PAS domain-containing protein 6