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Neuronal regeneration-related protein (NREP)
- Target
- NREP
- Molecular classification
- RNA-binding protein, Non-receptor intracellular protein, Other (intrinsically disordered protein)
01
Overview
Neuronal regeneration-related protein (NREP, also known as P311) is a small, intrinsically disordered RNA-binding protein predicted to regulate axon regeneration, neuronal differentiation, and transforming growth factor-beta (TGF-β) signaling. Highly expressed in developing tissues and after injury, it influences cellular migration, fibrogenic response, myofibroblast transformation, and TGF-β isoform translation in multiple organs. NREP interacts with translation machinery and cytoskeletal components to modulate key regenerative and remodeling events in the nervous system and peripheral tissues. Aberrant expression has been linked to pathological fibrosis, cancer progression, and impaired tissue repair.
- Other names
- P311C5orf13
02
Mechanism of action
Modulation of TGF-β translation and signaling; Interaction with translation initiation factors (eIF3b)
03
Biological functions
Axon regenerationRegulation of neuron differentiationRegulation of transforming growth factor beta (TGF-β) receptor signalingPromotion of cellular motility and migration (e.g., in fibroblasts, stem cells, glioma cells)Myofibroblastic transformation and fibrogenic responsesRegulation of actin dynamicsRegulation of epithelial-mesenchymal transition (EMT)Involvement in cell metabolism modulation (impact on lipid metabolism, phosphoinositide signaling, calcium flux)
04
Disease associations
Pulmonary fibrosisRenal fibrosisNonalcoholic fatty liver diseaseCancer (specifically, lung and non-small cell lung cancer, glioblastoma)Wound healing and tissue repairFamilial adenomatous polyposis (association reported)
05
Safety considerations
Targeting may interfere with wound healing, tissue repair, and normal fibrosis, leading to possible delayed healing or impaired regenerationModulation could influence off-target TGF-β signaling with pleiotropic effects across different tissues
06
Biomarkers
Fibrosis biomarker (expression correlates with severity of tissue remodeling in fibrotic diseases)Potential cancer biomarker
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