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Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 (NYAP2)
- Target
- NYAP2
- Molecular classification
- Other (neuronal adaptor protein, not a classical enzyme, receptor, transporter, ion channel, or transcription factor)[1][4][6]
01
Overview
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 (NYAP2) is a neuronally expressed adaptor protein belonging to the NYAP family (including NYAP1, NYAP2, and MYO16/NYAP3)[1][4]. NYAP2 is phosphorylated on tyrosine residues by the Src-family kinase Fyn after cell-surface stimulation, and subsequently binds the p85 regulatory subunit of phosphoinositide 3-kinase (PI3K). This links PI3K activation specifically in neurons with actin-remodeling via the WAVE1 complex, facilitating neurite elongation and neuronal morphogenesis. Disruption of NYAP family genes in mice results in reduced brain size and impaired neurite outgrowth. NYAP2 is not a classical therapeutic target, and there are no reported direct pharmacological modulators or disease biomarkers to date[1][2][4].
- Other names
- KIAA1486neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
02
Mechanism of action
Not applicable (no approved drugs or investigational agents with a defined mechanism of action targeting NYAP2)
03
Biological functions
Neuron projection morphogenesisSignal transduction (activation of PI3K pathway)Recruitment of WAVE1 complexRegulation of actin cytoskeleton and neurite elongation
04
Disease associations
Other (no strong evidence for major human disease roles, but NYAP2 is associated with neural development and morphology; some genetic association with Astigmatism reported)[4]
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