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Target intelligence / Profile preview
Neuronal Voltage-Gated Sodium Channel (NaV)
- Target
- NaV
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
Neuronal voltage-gated sodium channels are transmembrane proteins responsible for the rapid influx of sodium ions into neurons during action potentials. These channels are essential for neuronal excitability, enabling rapid depolarization and electrical signaling. Multiple isoforms exist (e.g., Nav1.1-Nav1.9), each with distinct expression patterns and functional properties. They are major drug targets for conditions like epilepsy and neuropathic pain. Mutations in sodium channel genes can lead to various neurological disorders.
- Other names
- Neuronal Sodium ChannelVoltage-Gated Sodium Channel (Neuronal)Sodium Channel Protein (Neuronal)
02
Mechanism of action
Voltage-dependent sodium ion influx leading to membrane depolarization; blocked by various compounds that prevent sodium ion passage.
03
Biological functions
Action potential initiationAction potential propagationNeuronal excitabilitySetting resting membrane potentialSynaptic integration
04
Disease associations
EpilepsyNeuropathic painAtaxiaMyopathy
05
Safety considerations
Cardiac arrhythmiaSeizuresNeurological side effects associated with non-selective channel blockade
06
Interacting drugs
Lidocaine
3 more in the full profile.
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