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Target intelligence / Profile preview
Neuropeptide Y receptor subtype 2 (Y2)
- Target
- Y2
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor, Class A/Rhodopsin-like GPCR
01
Overview
The neuropeptide Y receptor subtype 2 (Y2/NPY2R) is a presynaptically-expressed GPCR involved primarily with satiety signaling but also implicated broadly across neurological/endocrine functions due to its widespread distribution throughout brain regions like hippocampus/hypothalamus as well as peripheral tissues including gut epithelium. Its pharmacology includes both peptide agonists—especially truncated forms—and selective small-molecule antagonists useful for research into appetite control/anxiety/metabolic disease mechanisms.
- Other names
- NPY2RNPY receptor type 2
02
Mechanism of action
GPCR signaling modulation; inhibition of neurotransmitter release; appetite regulation
03
Biological functions
Signal transductionRegulation of food intake/appetite inhibition (satiety)Modulation of anxiety-related behaviorsControl of neurotransmitter release at presynaptic sitesRegulation of circadian rhythmAngiogenesis promotionBone homeostasis/formationVasoconstriction
04
Disease associations
Metabolic disordersObesityAnxiety disordersStress response alterationsBone metabolism disorders
05
Interacting drugs
Neuropeptide Y
6 more in the full profile.
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