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Target intelligence / Profile preview
Neuropeptide Y Receptor Subtype 4 (Y₄)
- Target
- Y₄
- Molecular classification
- G protein-coupled receptor, GPCR, Class A rhodopsin-like GPCR, Receptor
01
Overview
The Neuropeptide Y receptor subtype 4 (Y4) is a G protein-coupled receptor primarily activated by pancreatic polypeptide (PP). It plays a key role in appetite regulation, energy homeostasis, and other physiological functions. Due to its involvement in satiety signaling, it is considered a potential therapeutic target for metabolic diseases such as obesity.
- Other names
- NPY4RPancreatic Polypeptide Receptor 1PPYR1Y4PP1
02
Mechanism of action
Gi/o protein-coupled; inhibits adenylyl cyclase activity and cAMP production
03
Biological functions
Signal transductionAppetite regulationEnergy homeostasisRegulation of food intakeCircadian rhythm regulation of ingestionColonic motility regulationReproductive function modulation
04
Disease associations
Metabolic diseasesObesityEating disorders
05
Safety considerations
Potential for increased food intake with receptor blockade
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