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Target intelligence / Profile preview
Neuropeptide Y receptor subtype 5 (Y5)
- Target
- Y5
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
Neuropeptide Y receptor subtype 5 (Y5) is a G protein-coupled receptor that binds neuropeptide Y (NPY) and peptide YY (PYY). It is involved in regulating food intake, fat accumulation, and seizure modulation. It is located at the cell membrane and primarily signals via G proteins that inhibit adenylate cyclase activity. The Y5 receptor is implicated in feeding behavior, obesity, and may also play a role in certain cancers. It is a therapeutic target of interest for obesity prevention/treatment and radiopharmaceuticals relevant to cancer imaging or therapy.
- Other names
- NPY5 receptorNPY5R
02
Mechanism of action
Acts as a receptor for neuropeptide Y (NPY) and peptide YY (PYY), mediating effects via G proteins that inhibit adenylate cyclase activity.
03
Biological functions
Signal transductionAppetite stimulationRegulation of ERK1/ERK2 signaling pathwaysNegative regulation of acute inflammatory responsesChemical synaptic transmissionFat storageSeizure inhibition
04
Disease associations
ObesityFeeding disordersSeizuresCancer
05
Safety considerations
Potential side effects related to appetite modulationOff-target effects due to cross-reactivity with other Y receptors
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