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Target intelligence / Profile preview
Neuropeptide Y Receptor Type 4 (NPY4R)
- Target
- NPY4R
- Molecular classification
- G protein-coupled receptor, Rhodopsin-like GPCRs, Receptor
01
Overview
Neuropeptide Y receptor type 4 (NPY4R) is a G protein-coupled receptor that mediates the effects of pancreatic polypeptide signaling. It plays a pivotal role in appetite regulation and energy homeostasis by transmitting satiety signals after food intake. NPY4R is considered a promising therapeutic target for obesity and metabolic syndrome and is also implicated in certain cancers.
- Other names
- Pancreatic polypeptide receptor 1PPYR1NPY4-RPP1Neuropeptide Y receptor Y4
02
Mechanism of action
Negatively coupled to cAMP pathway
03
Biological functions
Appetite regulationEnergy homeostasisSignal transductionPancreatic polypeptide receptor activity
04
Disease associations
ObesityMetabolic disordersCancer
05
Safety considerations
Therapeutic challenges related to achieving selectivity and avoiding off-target effects within the NPY receptor family
06
Interacting drugs
Pancreatic polypeptide
7 more in the full profile.
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