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Target intelligence / Profile preview
Neuropeptide Y Receptor Type 5 (NPY5R)
- Target
- NPY5R
- Molecular classification
- G protein-coupled receptor, GPCR, Neuropeptide Y receptor
01
Overview
Neuropeptide Y receptor type 5 (NPY5R) is a G protein-coupled receptor (GPCR) that binds neuropeptide Y (NPY), peptide YY, and pancreatic polypeptide. It plays a role in appetite regulation, energy homeostasis, modulation of neuronal activity, cell growth signaling, and synaptic transmission. It has been implicated in epilepsy and certain cancers such as neuroblastoma, breast cancer and liver cancer.
- Other names
- NPYR5NPY5-RNPYY5-R
02
Mechanism of action
Activation of presynaptic Y5 receptors induces a sustained increase in spontaneous GABA release from inhibitory neurons. Activation inhibits adenylate cyclase activity leading to decreased cAMP levels. Activation can also trigger ERK signaling pathways promoting cell proliferation.
03
Biological functions
Appetite regulationEnergy homeostasisNeuronal activity modulationGABAergic transmissionCell proliferationSignal transductionSynaptic transmission
04
Disease associations
EpilepsyNeuroblastomaBreast cancerLiver cancer
05
Safety considerations
Potential for off-target effects due to NPY's involvement in various physiological processes.
06
Interacting drugs
Neuropeptide Y
9 more in the full profile.
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