Neuropeptide Y receptor type 6 (NPY6R)

Neuropeptide Y receptor Y6 (NPY6R) is one of several members of the NPY receptor family, which are G protein-coupled receptors (GPCRs) typically involved in signal transduction for neuropeptide Y, peptide YY, and pancreatic polypeptide. However, while five NPY receptor subtypes have been identified in mammals (Y1, Y2, Y4, Y5, Y6), only four (Y1, Y2, Y4, Y5) are functional in humans[2][3]. The Y6 receptor is nonfunctional in humans due to premature stop codons and truncations in the gene, although a functional form is present in some animals such as rabbit and mouse[2]. There is no evidence that NPY6R serves as a functional receptor or a drug target in humans, and it has no established role in disease or as a biomarker. Its classification as a therapeutic target is therefore incorrect for humans. NPY6R is a pseudogene or nonfunctional in humans, with reports confirming that it does not encode a functional protein and has no established biological or clinical role in humans[2]. The receptor is functional in species such as rabbit and mouse, but not in humans due to genetic inactivation[2]. No approved drugs or ligand interactions are currently described for NPY6R in humans. Current clinical and research literature classifies only Y1, Y2, Y4, and Y5 as functional NPY receptors in humans[2][3]. There are no known safety or biomarker issues because NPY6R does not have functional expression or therapeutic relevance in humans. If you are cataloging druggable targets or clinically relevant NPY receptors, NPY6R should not be included as a functional or druggable human target.

Other names

Putative neuropeptide Y receptor type 6NPY6RNPY1RLY2BNPY6-RPP2NPY6RPNPY Y1-like receptorPutative pancreatic polypeptide receptor 2