Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Neuropilin-1 (NRP-1)
- Target
- NRP-1
- Molecular classification
- Transmembrane glycoprotein, Receptor, Coreceptor
01
Overview
Neuropilin-1 (NRP-1) is a multifunctional transmembrane glycoprotein receptor/coreceptor encoded by the *NRP1* gene, widely expressed across neuronal/vascular/immune tissues. It mediates crucial developmental processes—including axon guidance/neurogenesis/cardiovascular morphogenesis—and plays central roles in adult pathologies such as cancer progression/metastasis/immunosuppression via interactions mainly involving class III semaphorins & VEGF family ligands/receptors. Its structural features enable highly selective ligand recognition making it an attractive target for anti-cancer therapies—and potentially antiviral interventions—currently under active investigation.
- Other names
- NRP1BDCA4CD304VEGF165RNeuropilin 1
02
Mechanism of action
Inhibition of NRP-1 mediated signaling, blocking ligand binding, disruption of NRP-1 interactions with other receptors
03
Biological functions
Axon guidanceAngiogenesisImmune regulationCell survivalCell migrationCell invasionVEGF signalingTGFβ signaling
04
Disease associations
CancerOcular neovascular diseasesCOVID-19Tumorigenesis
05
Safety considerations
Potential for off-target effects due to widespread expressionDisruption of normal physiological functions (e.g., angiogenesis, neural development)
06
Interacting drugs
Small molecule inhibitors/antagonists
3 more in the full profile.
07
Biomarkers
NRP-1 expression levels in tumor tissueNRP-1+ Tregs in tumor microenvironment
Beyond the preview
Go deeper on Neuropilin-1 (NRP-1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Neuropilin-1 (NRP-1).