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Target intelligence / Profile preview
Neuropilin-1 Receptor (NRP1)
- Target
- NRP1
- Molecular classification
- Transmembrane glycoprotein, Receptor
01
Overview
Neuropilin-1 (NRP1) is a non-tyrosine kinase transmembrane glycoprotein that functions as a co-receptor for various ligands, including vascular endothelial growth factor A (VEGFA) and class 3 semaphorins such as SEMA3A. It plays critical roles in angiogenesis, neuronal development, immune regulation, and cell migration/survival. NRP1 is widely expressed and upregulated in many cancers, making it an attractive therapeutic target.
02
Mechanism of action
Targeting NRP1 may enhance cancer immunotherapy efficacy without compromising peripheral tolerance. Facilitates SARS-CoV-2 entry into host cells; considered a potential antiviral drug target due to this function.
03
Biological functions
AngiogenesisAxon guidanceImmune regulationCell migrationCell survival
04
Disease associations
CancerCOVID-19Developmental Disorders
05
Safety considerations
Embryonic lethality in knockout modelsPotential for impaired arteriogenesis or neuronal circuit formation
06
Biomarkers
Expression levels in tumors as a prognostic marker
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