Target intelligence / Profile preview

Neuropilin-2 (NRP2)

Target: NRP2
Molecular classification: Single-pass type I membrane protein, Receptor

Overview

Neuropilin-2 (NRP2) is a transmembrane receptor protein involved in axon guidance, angiogenesis, and lymphangiogenesis. It acts as a coreceptor for class III semaphorins and VEGFs, playing roles in cardiovascular development, tumorigenesis, inflammation and potentially in aspects of cardiovascular disease. NRP2 interacts with VEGFRs and Plexins to mediate downstream signaling. It is implicated in cancer progression/metastasis and its expression may be upregulated in metastatic tumors, making it a therapeutic target.

Mechanism of action

N/A

Biological functions

Axon guidanceAngiogenesisLymphangiogenesisCardiovascular developmentModulates immune cell migration

Disease associations

CancerCardiovascular diseaseInflammationInfection

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