Neuroprotection pathway

"Neuroprotection pathway" is not a specific molecule or receptor but refers broadly to a collection of molecular signaling cascades that promote neuronal survival and protect against cell death in the context of neurological injury or disease. These pathways include activation of pro-survival kinases such as PI3K/Akt—which can inhibit apoptosis through downstream targets like BAD and survivin—as well as modulation by nitric oxide synthase enzymes and changes in ion channel permeability. Natural products such as terpenoids have been shown experimentally to exert neuroprotective effects via these pathways. Because "neuroprotection pathway" is not a discrete molecular entity but an umbrella term for multiple interconnected biological processes and targets involved in neuronal protection, it should not be considered a canonical therapeutic target itself but rather a functional concept encompassing many potential drug targets within its network.

Other names

Neuroprotection pathwayneuroprotective pathwayneuroprotective signaling pathways

Activation of pro-survival kinases (e.g., PI3K/Akt), anti-apoptotic protein induction (e.g., BAD, survivin), modulation of ion channels and mitochondrial function, epigenetic regulation of gene expression related to neuronal survival