Neurotensin Receptor 2 (NTS2)

Neurotensin receptor 2 (NTS2), also known as NTR2, is a G protein-coupled receptor (GPCR) that primarily binds the neuropeptide neurotensin. It is involved in modulating several physiological processes, especially within the central nervous system, including dopamine signaling, pain modulation, and thermal regulation. Its unique pharmacology, particularly its high sensitivity to levocabastine and the development of selective synthetic ligands, makes it a promising target for non-opioid analgesics and potential treatments for psychiatric or neurological disorders.

Other names

NTR2NT2RLevocabastine-sensitive neurotensin receptorHigh-affinity levocabastine-sensitive neurotensin receptor

Activation of phosphatidylinositol-calcium second messenger system; competitive binding with neurotensin at the receptor site.