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Neurotensin receptor 1 (NTSR1)
- Target
- NTSR1
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor, Class A GPCR, Rhodopsin-like GPCR
01
Overview
Neurotensin receptor 1 (NTSR1) is a G protein-coupled receptor that mediates diverse physiological effects through neurotensin signaling. It is involved in processes like hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. It has been implicated in Parkinson’s disease and Schizophrenia. Several high-resolution structures are available for NTSR1, complexed with peptide agonists, non-peptide agonists, partial agonists, antagonists/inverse agonists, and in the ligand-free state.
- Other names
- Neurotensin receptor type 1
02
Mechanism of action
Activation of G proteins (primarily Gq/11 family) leading to phosphatidylinositol-calcium second messenger system activation and downstream MAP kinase activation.
03
Biological functions
Signal transductionRegulation of intestinal motilityRegulation of intestinal secretionAntinociceptionCell protection against apoptosis
04
Disease associations
Parkinson’s diseaseSchizophreniaPain
05
Safety considerations
HypotensionHyperglycemiaHypothermiaNo clinically approved drugs directly targeting human NTSR1 are currently available.
06
Interacting drugs
Neurotensin
6 more in the full profile.
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