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Neurotensin Receptor Type 2 (None)
- Target
- None
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
Neurotensin receptor type 2 (NTSR2) is a G protein-coupled receptor that binds the neuropeptide neurotensin. It is predominantly expressed in the brain, particularly in astrocytes, and plays roles in neuromodulation, analgesia, and modulation of fear memory. NTSR2 represents a potential therapeutic target for pain management, with selective agonists showing promise for potent analgesia without the side effects associated with broader neurotensin receptor activation. There is also research into the potential role of NTSR2 in cancer cell survival.
- Other names
- Neurotensin receptor 2NTR2
02
Mechanism of action
Agonist or antagonist binding to NTSR2, modulating downstream signaling pathways.
03
Biological functions
Signal transductionModulation of dopamine neurotransmissionRegulation of body temperatureAnalgesiaModulation of fear memory
04
Disease associations
PainCancer
05
Safety considerations
Potential for side effects related to neurotensin signaling if agonists are not highly selective for NTSR2.
06
Interacting drugs
Neurotensin
1 more in the full profile.
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