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Neurotrophic Factor Signaling Pathway (Neurotrophin Signaling Pathway)
- Target
- Neurotrophin Signaling Pathway
- Molecular classification
- Signaling Pathway, Receptor Tyrosine Kinase Pathway, Cellular Signaling
01
Overview
The neurotrophic factor signaling pathway is a critical molecular cascade in the nervous system that regulates neuronal survival, differentiation, growth, and synaptic plasticity. This pathway is primarily mediated by a family of secreted proteins called neurotrophins and their corresponding receptors, including Trk receptors and p75NTR. Dysregulation has been implicated in various neurological disorders.
- Other names
- Neurotrophin PathwayNGF signaling pathwayBDNF signaling pathwayNT-3 signaling pathwayNT-4 signaling pathway
02
Biological functions
Neuronal survivalNeuronal differentiationAxonal growthSynaptic plasticityLearningMemory formationNeural developmentApoptosis regulation
03
Disease associations
Alzheimer's diseaseDepressionSchizophreniaNeuropathic painBrain injuryNeurodegenerative disease
04
Safety considerations
Off-target effectsDysregulation leading to apoptosisBalancing pro-survival and pro-apoptotic signals
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