Target intelligence / Profile preview

Neurotrophic Receptor Tyrosine Kinase 3 (NTRK3)

Target: NTRK3
Molecular classification: Receptor tyrosine kinase, Tropomyosin-related kinase (Trk) family

Overview

NTRK3 is a receptor tyrosine kinase that binds neurotrophin-3 (NT-3) to regulate neural development, survival, and differentiation. Activation triggers downstream signaling cascades involving PLCG1, PI3K, and RAAS pathways. It plays a complex role in cancer, acting as an oncogene in some contexts and a tumor suppressor in others. Mutations and dysregulation are linked to various diseases, including neurodegenerative disorders and cancers.

Other names: TrkC

Mechanism of action

Tyrosine kinase inhibition upon ligand binding

Biological functions

Neural developmentExcitatory synapse formationCell survivalCell proliferationCell motilitySynaptogenesisDifferentiationSignal transduction

Disease associations

FibrosarcomaCongenital Mesoblastic NephromaUpper tract urothelial carcinomasHepatocellular carcinomaNeuroblastomaBreast cancerProstate cancerPancreatic cancerColorectal cancerDilated cardiomyopathyPrimary ovarian insufficiencyAlzheimer's diseaseParkinson's diseaseHuntington's diseaseAmyotrophic lateral sclerosis

Safety considerations

Potential for off-target effects with tyrosine kinase inhibitorsTumor promotion or suppression depending on context

Biomarkers

Expression levels in various cancers (prognostic/predictive)

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