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Target intelligence / Profile preview
Neurotrophic Receptor Tyrosine Kinase Family (TRK)
- Target
- TRK
- Molecular classification
- Receptor, Tyrosine Kinase Receptor
01
Overview
The neurotrophic receptor tyrosine kinase (TRK) family consists of TrkA, TrkB, and TrkC, which are high-affinity receptors for neurotrophins. These receptors play crucial roles in the development, function, and maintenance of the nervous system. Upon ligand binding, TRKs dimerize and autophosphorylate, activating downstream pathways like RAS/MAPK and PI3K/Akt, influencing neuronal survival, differentiation, and synaptic plasticity. Dysregulation or mutations involving NTRK genes, particularly gene fusions, can drive oncogenesis in various cancers. They interact with other molecules such as NCAMs further modulating neurite outgrowth.
- Other names
- Tropomyosin receptor kinase familyTrkATrkBTrkCNTRK1NTRK2NTRK3
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Neuronal survivalDifferentiationSynaptic plasticityNeurite outgrowthSignal transduction
04
Disease associations
CancerNeurological disorders
05
Safety considerations
Oncogenesis through gene fusionsPotential impact on neural development/function
06
Biomarkers
NTRK gene fusions
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