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Target intelligence / Profile preview
Neurotrophic receptor tyrosine kinases (NTRK)
- Target
- NTRK
- Molecular classification
- Receptor, Tyrosine Kinase, Receptor Tyrosine Kinase
01
Overview
The neurotrophic receptor tyrosine kinases NTRK1, NTRK2, and NTRK3 encode the transmembrane receptor tyrosine kinases TRKA, TRKB, and TRKC, respectively. These receptors are high-affinity binding sites for neurotrophins and play essential roles in neural development, survival, and function. Aberrant activation, particularly through gene fusions, drives oncogenesis in diverse cancers, making them key targets for precision oncology with TRK inhibitors. Loss-of-function mutations are implicated in neurological disorders.
- Other names
- TRKTropomyosin receptor kinase ATropomyosin receptor kinase BTropomyosin receptor kinase CTrkATrkBTrkCNTRK1NTRK2NTRK3
02
Mechanism of action
Selective inhibition of TRK kinase activity
03
Biological functions
Neural developmentNeuronal survivalDifferentiationSynaptic plasticitySignal transductionCell survivalCell proliferationApoptosis
04
Disease associations
CancerNeurological disordersEpilepsyDepression
05
Safety considerations
Resistance to TRK inhibitorsOff-target effects of TRK inhibitors
06
Interacting drugs
TRK inhibitors
07
Biomarkers
NTRK fusions
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