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Neurotrophic Support System (N/A)
- Target
- N/A
- Molecular classification
- Growth Factor Signaling Pathway, Receptor Tyrosine Kinase Pathway, Neurotrophin, Receptor, Kinase Signaling
01
Overview
The neurotrophic support system encompasses the action of neurotrophic factors, such as NGF, BDNF, NT-3, and NT-4/5, which promote the growth, survival, differentiation, and maintenance of neurons. These factors signal through Trk receptors (TrkA, TrkB, TrkC) and the p75NTR receptor, influencing neuronal plasticity, synaptic efficacy, learning, memory formation, and regeneration after injury. Dysregulation of this system is implicated in various neurodegenerative and psychiatric disorders.
- Other names
- Neurotrophin SignalingNerve Growth Factor PathwayBrain-Derived Neurotrophic Factor PathwayNeurotrophin-3 PathwayNeurotrophin-4/5 PathwayNGF PathwayBDNF PathwayNT-3 PathwayNT-4/5 Pathway
02
Mechanism of action
Activation of Trk receptors (TrkA, TrkB, TrkC) leads to downstream signaling cascades including MAPK and PI3K/Akt pathways, which promote neuronal survival, growth, and differentiation. Modulation of p75NTR can either enhance or antagonize Trk signaling.
03
Biological functions
Neuron survivalNeuron growthNeuron differentiationAxon growthAxon guidanceSynaptic plasticityLong-term potentiationMemory formationNeuroprotectionNeuronal regeneration
04
Disease associations
Alzheimer's diseaseHuntington's diseaseDepressionAnxiety disordersPainNeurodegenerative diseaseAutoimmune diseaseNeurological disorders
05
Safety considerations
Off-target effects of neurotrophin therapiesPotential for uncontrolled neuronal growth or differentiationImmune responses to neurotrophinsp75NTR activation leading to apoptosis under certain conditions
06
Biomarkers
BDNF levelsNGF levelsTrkA expressionTrkB expressionTrkC expressionp75NTR expression
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