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Target intelligence / Profile preview
Neurotrophic Tyrosine Kinase Receptor Type 2 (TrkB)
- Target
- TrkB
- Molecular classification
- Receptor Tyrosine Kinase
01
Overview
Neurotrophic Tyrosine Kinase Receptor Type 2 (NTRK2), also known as TrkB, is a receptor tyrosine kinase that mediates the effects of neurotrophins, particularly Brain-Derived Neurotrophic Factor (BDNF), Neurotrophin-3 (NT-3), and Neurotrophin-4/5 (NT-4). It plays a critical role in neuronal development, differentiation, survival, and synaptic plasticity. Dysregulation or mutations in NTRK2 have been implicated in obesity syndromes and cancer.
- Other names
- Tropomyosin receptor kinase B
02
Mechanism of action
Tyrosine kinase receptor activation by neurotrophins (BDNF, NT-3, NT-4) leading to downstream signaling via Ras-MAPK/ERK, PI3K-Akt, and PLCγ pathways.
03
Biological functions
Neuronal survivalNeuronal differentiationSynaptic plasticityAxon growthDendrite growthAstrocyte morphogenesisAstrocyte maturation
04
Disease associations
Obesity syndromesCancer
05
Safety considerations
Aberrant signaling can promote tumorigenesis
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